Synthetic Ligands

Low molecular weight ligands that mimic the action of biologics have gained popularity not only in drug discovery and enzyme inhibition but also in several protein purification applications. The use of synthetic chemistry for the generation of compounds bound to a solid support (resin beads, silica surfaces or plastic pins) or in solution (for latter derivatization) is a fundamental yet powerful tool. However, nonspecific binding is a major disadvantage and has prompted the emergence of rationally designed ligands or bio-mimetics. These biomimetics have endearing properties such as high stability, defined chemical structure and toxicity, resistance to degradation, inexpensive-ness and sterilizability in situ. They mimic the action of natural counterparts of proteins and can selectivity extract the protein of interest. The devel opment of such synthetic molecules has been inspired and aided by the increasing availability of protein structural data and knowledge about protein-ligand complexes.

Synthetic combinatorial libraries comprising several hundreds to tens of millions of compounds are potential sources for drugs, enzyme inhibitors and antimicrobials. Pepetidomimetic and organic libraries are yielding compounds to replace biomolecules for easier manipulation of the physical, chemical and biological properties and to address issues related to cost and availability. Oligomeric N-substituted glycines (NSG) or peptoids are novel polymers that are also being widely used for generation of vast chemical libraries. They are achiral, protease-resis-tant, inexpensive and are hydrolytically and enzym-atically stable.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

Get My Free Ebook


Post a comment