Membrane processes should continue to be of critical importance in bioprocessing applications, facilitating the cost-effective production of a wide range of biological products. Ultrafiltration has become the primary means for protein concentration and buffer exchange in the production of therapeutic proteins and industrial enzymes. Sterile filtration is used throughout the bioprocessing industry, and viral filtration is of growing importance in the production of blood products and therapeutic recombinant proteins.

The future is likely to see the continued development of high performance tangential flow filtration as a viable alternative to existing separation technologies for protein purification. There is also growing interest in the development of membrane systems for the preparation of enantiomerically enriched antibiotics, nutraceuticals and pharmaceuticals. These membrane systems use chiral ligands to separate ra-cemic mixtures or they employ immobilized enzymes for direct production of single enantiomers in membrane reactors. Affinity membrane systems are also being actively pursued as alternatives to standard chromatographic resins for a range of adsorptive bioseparations. In this case, the membrane provides an attractive high surface area support with minimal diffusional mass transfer resistance. New advances in membrane materials, modules and processes should lead to continued development of membrane systems for bioseparations.

See also: II/Membrane Separations: Microfiltration;


Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

Get My Free Ebook

Post a comment