Principles of Magnetic Separation of Cells

Two types of magnetic separation can be distinguished when working with cells. In the first type, cells to be separated demonstrate sufficient intrinsic magnetic moment so that magnetic separations can be performed without any modification. There are only two types of such cells in nature: magnetotactic bacteria containing small magnetic particles within their cells and red blood cells (erythrocytes) containing high concentrations of paramagnetic haemoglobin. In the second type, cells of interest have to be tagged by a magnetic label to achieve the required contrast in magnetic susceptibility between the labelled and unlabelled cells. The attachment of magnetic labels is usually attained by the use of affinity ligands of various types, which can interact with target structures on the cell surface. Usually antibodies microbial pathogens) and parasitology (isolation and detection of protozoan parasites). No doubt many new processes and applications in other fields of biosciences and biotechnologies will be developed in the near future.

See also: II/Centrifugation: Analytical Centrifugation; Large-Scale Centrifugation. III/Cells and Cell Organelles: Field Flow Fractionation.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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