Future Developments

Electrochemically modulated liquid chromatography is emerging as a valuable addition to the arsenal of liquid chromatographic techniques used in tacking the many challenges encountered in the day-to-day operations of the analytical laboratory. Advances in this area will continue with improvements in column design that reduce the equilibration time to changes in applied potential. Such developments will enhance the ability of the analyst to manipulate separations by dynamically altering the applied potential during analyte elution.

There are also several intriguing opportunities in the creation of separation formats using new types of stationary phases. Other types of conducting phases based, for example, on electrochemically transformable coatings offer pathways to manipulate separations by variations in the porosity of a coating which can be affected by the size of the dopant ion used in the electrochemical coating process. Variations in porosity may add size discrimination to the selectivity of the separation process. In addition, the incorporation of functional groups as substituents on the monomer precursors used for polymer formation can be exploited to design coating with hydrophobic-ity-hydrophilicity differences.

Another area of fruitful development lies in the coupling of this technique to other detector formats. Mass spectrometry, for instance, has proven invaluable as a detector in a wide range of chromatographic applications. The ability of electrochemically modulated liquid chromatography to address separations that require the use of gradient-elution strategies may overcome the associated problems of a continuing changing background when using electrospray mass spectrometry. Enhancements may also be realized by electrochemically transforming an analyte to a form that improves not only its separation but also its response to conventional optical detection formats. These developments, coupled with systematic explorations of the interactions operative in the many retention mechanisms, promise to stimulate the widespread interest in this new mode of liquid chromatographic separations.

See also: Ill/Steroids: Liquid Chromatography and Thin-Layer (Planar) Chromatography. Chiral Separations: Cyclodextrins and Other Inclusion Complexation Approaches; Liquid Chromatography.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

Get My Free Ebook


Post a comment