Future Developments

Convective chromatographic media have found applications in the preparative chromatography of peptides and proteins. The use of these materials in preparative and industrial scale simulated moving bed (SMB) technology for chromatographic processes will eventually occur in view of the trade-off between pressure drop and packing efficiency; the simplified design of the SMB unit with simple linear driving force models to describe intraparticle mass transfer is straightforward, using an apparent mass transfer coefficient k = k/f (X).

Figure 10 Normalized breakthrough curves for BSA 2 mg mL~1, c/cb versus t/tst, on POROS Q/M column at various flowrates. Continuous line, 2 mL min"1; dashed line, 5 mL min"1; dotted line, 7mLmin~1. (Reprinted from Rodrigues AE et al. (1996) Protein separation by liquid chromatography using POROS Q/M particles. ChemicalEngineeringJournal61: 191-201, with permission from Elsevier Science.)

Continuous bed technology is a promising area which allows convective flow in wider channels and at the same time smaller diffusion limitations in microspheres since they have a very small diameter.

See also: N/Chromatography: Size Exclusion Chromatography of Polymers. Chromatography: Liquid: Mechanisms: Size Exclusion Chromatography. III/Peptides and Proteins: Liquid Chromatography.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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