Functional Monomers

Functional monomers are selected based on their ability to bind reversibly, via either covalent or non-covalent bonds, to the analyte. In covalent imprinting approaches, the covalent bonds linking the functional monomers to the analyte need to be reasonably labile to allow removal of the analyte from the polymer matrix under relatively mild conditions. This requirement is somewhat limiting, and only metal-chelates, boronic acid esters, disulfides and Schiff bases have been developed to any great extent. The non-covalent approach is much less restricting in this respect, and numerous vinyl-based monomers have been successfully employed (Table 2).

In non-covalent imprinting protocols, the ana-lyte-functional monomer assembly is dynamic in that the functional monomers exist in both the free and the complexed state, and indeed are free to move from one state to another. To push the equilibrium towards assembly formation, it is not unusual to use an excess of functional monomer in the polymerization mixture (typically two-fold or greater). This does have the side effect of increasing the level of non-specific rebinding of the analyte to the polymer, but at the same time it increases the number of good binding sites, so it is a compromise.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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