Flavanones

Flavanones occur in nature and have been isolated in an optically active form. They contain only hydroxyl and methoxy groups and differ from one another in the number and/or position of such substituents (Table 9).

With the exception of glycosides, 5-methoxy-, 7-hydroxy- and 5-hydroxy-7-methoxyflavanone, the enantiomers of the tested compounds can be separated by at least one of the chiral phases reported in Table 10.

In the series of flavanones no chiral discrimination was observed on MCTA plates for racemic 2'-hy-droxy-, 4'-hydroxy- and 4'-methoxyflavanone in contrast to polysubstituted compounds. Partial resolution was obtained for flavanone, 6-methoxy- and 6-hydroxyflavanone. Two successive developments with the same eluent (ethanol-water, 80 : 20 v/v) effectively improves the separation of these racemates on MCTA layers.

The addition of ft-CD to the mobile phase permits separation of enantiomeric flavanone and its 2'-hy-droxy-, 4'-hydroxy- and 4'-methoxy derivatives.

Albumin is able to resolve racemic polysubstituted flavanones and 2'-hydroxyflavanone. Alkaline mobile phases must be used for their separation.

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