Conclusions

Much has changed over the last few years in both the manufacture of support materials and the design of columns. Manufacturers of supports now make more reproducible materials and very pure forms of support materials, especially in silica, where metal impurity levels are now less than 5 ppm (the first silicas used had typical impurity levels of 1000-2000 ppm). In the silica support materials the latest developments have been towards base-deactivated materials and have tended to focus on the new very pure silicas. Particle size distributions have also become tighter around given means, leading to more stable and reproducible columns.

In column design, the move has been to cartridge type systems having smaller tube i.d. with smaller particles and shorter lengths.

The focus on development is now moving to micro systems. Future developments are likely to be systems with smaller and smaller column i.d., and even complete columns on microchips.

See Colour Plates 21, 22.

See also: II/Chromatography: Liquid: Mechanisms: Reversed Phases. III/Porous Graphitic Carbon: Liquid Chromatography. Porous Polymers: Liquid Chromatography.

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