Chiral Separations

Initial studies on noncovalent MlPs focused mainly on the preparation of materials selective for amino acid derivatives. The polymers possessed not only a selectivity for the amino acid used as the print molecule, but were also found to be enantioselective; the enantiomer present during the polymerization was preferentially bound. These findings, together with observations that the polymers were mechanically and chemically stable, made them attractive as CSPs and spurred further research.

The imprinting effects of MIPs prepared with optically active compounds as the print molecules are readily demonstrated by chromatographic evaluation. For example, when the l-enantiomer of an amino acid derivative is used as the print species, a column packed with the resulting polymer will retain the l-enantiomer longer than the d-enantiomer, and vice versa when the d-enantiomer is used as the print molecule. Reference polymers prepared with the racemate or without print molecule will not be able to resolve the racemate. A stereoselective memory is hence induced in the polymers by the print molecules.

Molecularly imprinted CSPs have been prepared for applications in high performance liquid chromatography (HPLC), thin-layer chromatography (TLC), capillary electrophoresis (CE) and capillary electrochromatography (CEC). CSPs for HPLC are by far the most studied.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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