Chiral Derivatization

separable on achiral GC or HPLC columns or TLC plates was the first, widely used general method in the chiral analysis of drugs and related materials. After the introduction of newer chromatographic and capillary electrophoretic techniques briefly mentioned above, the importance of enantioseparations based on covalent chiral derivatization has naturally decreased to some extent. However, this general method is still a method of choice widely used especially in HPLC. The reasons for this are the large number of commercially available homochiral reagents and well-established reactions enabling dias-tereomeric derivatives with excellent separation and detection possibilities to be formed and the possibility of tailor-made separations using inexpensive, achiral columns, i.e. being in possession of the R- and S-forms of the reagent, it is possible to have the peak of the enantiomeric impurity eluting before the main peak.

The importance of covalent chiral derivatization can be characterized by the large number of publications (above 300) from the early 1970s up to the present time. References to the most important publications from this field can be found in chapters in books and review papers listed in Further Reading which cover the literature until 1993. The relatively large number of papers published after 1993 describing new applications of previously described derivat-ization reagents, moreover the introduction of new reagents is an indication that this branch of chiral analysis has retained some of its importance to the present day (see figure legends).

Solar Panel Basics

Solar Panel Basics

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