Although the principle of Prep-SFC is well established, its commercial availability is relatively new so that there are only a limited number of published applications. One of the first and most studied applications with an industrial opening is the purification of ro-3 unsaturated fatty acids from fish-oil extracts. More precisely, the ethyl esters of eico-sapentaenoic acid (C22:5) and docosahexaenoic acid (C20:6) are required at a relatively high purity. Pure carbon dioxide is used as an eluent. There is no difficulty in solubilizing the ethyl esters. Large-scale production is envisaged (tens of tons per year). The costing of the process shows that separation by Prep-SFC is two to five times cheaper than Prep-HPLC and the quality of the final product is better.

More recently, other applications have been patented among which one important example is the purification of cyclosporine (a cyclic undecapeptide) with carbon dioxide and an alcohol as modifier. Among the emerging applications under study many chiral separations are candidates to be performed by Prep-SFC. One separation example described below in more detail has been developed in the authors' facilities.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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