Amino Acid Derivative Enantioseparation via Molecular Imprints

Molecular imprinted polymers (MlPs) are produced by preparing a polymer (usually prepared from a methacrylic acid, styrene or 4-vinylpyridine monomer template cross-linked with ethylenedimethyl-methacrylate) in the presence of an imprint, or template, molecule. When the template is subsequently removed it leaves a cavity capable of 'recognizing' and selectively rebinding the imprinted compound. This property allows discrimination between enantio-mers and has been used as the basis for the development of CSPs for the highly selective separation of amino acid derivatives (e.g. dansyl, anilide, BOC-1-amino acid anilides, etc.) and a number of examples of this type of separation have been published. A typical example would be the use of a molecular imprint to the amino acid derivative l-phenylalanine anilide for the resolution of a mixture of the two enantiomers of the print molecule. In this case the more retained enantiomer is the l-form of the amino acid derivative as it exhibits a greater affinity for the stationary phase. In general the imprinted polymers are most selective for the particular print molecule used to prepare them. However, there are examples of the separation of enantiomers of non-imprint molecules as well.

Solar Panel Basics

Solar Panel Basics

Global warming is a huge problem which will significantly affect every country in the world. Many people all over the world are trying to do whatever they can to help combat the effects of global warming. One of the ways that people can fight global warming is to reduce their dependence on non-renewable energy sources like oil and petroleum based products.

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